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Conoce los usos de ZOLADEX 10.8MG IMPLANTE C1

Zoladex is a medicine that can be used in the treatment of advanced prostate cancer. It works in a similar way to Lorelin and has demonstrated its effectiveness and safety in different clinical trials.

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What is ZOLADEX 10.8MG IMPLANT C1 and how does it work?

The active substance in Zoladex is goserelin, a synthetic analogue of gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH). Goserelin acts at the level of the hypothalamic pituitary axis, inhibiting the production of GnRH. In this way, the testosterone production in the testicles decreases.

The decrease in testosterone level helps in the control of prostate cancer. ZOLADEX 10.8MG IMPLANTE C1 works in a similar way to Lorelin injectable suspension, with comparable levels of effectiveness and safety.

It is important to note that during the first days after the administration of Zoladex, there will be an increase in gonadotropins, which may exacerbate the patient’s symptoms. The continuous administration (through the quarterly implant for example) is what allows to reduce the level of testosterone in the long term. In this way it will be possible to control the symptoms of the disease.

Administration

ZOLADEX 10.8MG IMPLANTE C1 is administered subcutaneously, in the abdominal wall. This medicine is absorbed quickly, the maximum plasma level is obtained 24 hours after application. Then its level drops and remains stable.

Uses of ZOLADEX 10.8MG IMPLANT C1

These are the indications of Zoladex 10.8mg:

  • Palliative treatment of advanced prostate cancer, especially when estrogen therapy or orchiectomy is not adequate or not accepted by the patient.
  • Treatment of locally confined prostate cancer, in combination with radiotherapy and flutamide.

As mentioned above, the administration of Zoladex in a quarterly implant results in a decrease in the concentration of testosterone at levels similar to those of surgical castration. In patients with prostate cancer, this hormonal decline helps stop the growth of cancer cells, reduce the size of the prostate and decrease associated symptoms.

Contraindications and warnings

  • Hypersensitivity (allergy) to goserelin or any of the other components of ZOLADEX 10.8MG IMPLANT C1.
  • This medicine should NOT be used in children.
  • Zoladex 10mg is also not indicated for use in women with breast cancer or endometriosis (in these cases Zoladex 3.6 mg can be used)

Before starting treatment, tell your doctor if you have diabetes, high blood pressure, depression, mood swings, bone problems or cardiovascular disease.

Adverse side effects

Reducing the concentration of testosterone in blood to minimal levels can cause erectile dysfunction (impotence, erection problems), decreased sexual desire and gynecomastia.

Other possible side effects are: elevated blood glucose level, hypercalcemia, anaphylactic or anaphylactoid reaction, increased blood pressure.

 

Effectiveness and safety of treatment with ZOLADEX 10.8MG IMPLANT C1

Different scientific studies show that treatment with Zoladex 10.8 mg is able to reduce the level of testosterone to less than 0.3 mcg from week 4 after administration of the drug. The level of testosterone remains at the same level during the remaining weeks of treatment.

In 90% of patients Zoladex 10.8mg decreases the level of prostate-specific antigen (PSA). Although in some patients a decrease in sexual desire is observed, other adverse side effects (hot flashes, pelvic pain) are rare.

In summary, the administration of ZOLADEX 10.8MG IMPLANTE C1 every 13 weeks in patients with advanced prostate cancer is a well tolerated treatment, which suppresses blood testosterone, decreases the level of PSA and produces positive, subjective and objective responses in patients .

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